杭州浙大迪迅生物基因工程有限公司Allergy：双胞胎儿童哮喘的遗传研究
发布日期：2018-11-26
原标题：双胞胎儿童哮喘遗传力和遗传证明的关联研究
延伸阅读
Allergy
DOI: 10.1111/all.12783
Abstract:
Background: Although the genetics of asthma has been extensively studied using both quantitative and molecular genetic analysis methods, both approaches lack studies specific to the childhood phenotype and including other allergic diseases.This study aimed to give specific estimates for the heritability of childhood asthma and other allergic diseases, to attempt to replicate findings from genomewide association studies (GWAS) for childhood asthma and to test the same variants against other allergic diseases.
Methods: In a cohort of 25 306 Swedish twins aged 9 or 12 years, data on asthma were available from parental interviews and population-based registers. The interviews also inquired about wheeze, hay fever, eczema, and food allergy. Through structural equation modeling, the heritability of all phenotypes was calculated. A subset of 10 075 twins was genotyped for 16 single nucleotide polymorphisms (SNPs) selected from previous GWAS; these were first tested for association with asthma and significant findings also against the other allergic diseases.
Results: The heritability of any childhood asthma was 0.82 (95% CI 0.79–0.85).For the other allergic diseases, the range was approximately 0.60–0.80. Associations for six SNPs with asthma were replicated, including rs2305480 in the GSDMB gene (OR 0.80, 95% CI 0.74–0.86, P = 1.5*108; other significant associations all below P = 3.5*10^4). Of these, only rs3771180 in IL1RL1 was associated with any other allergic disease (for hay fever, OR 0.64, 95% CI 0.53–0.77, P = 2.5*10^6).
Conclusions: Asthma and allergic diseases of childhood are highly heritable, and these high-risk genetic variants associated specifically with childhood asthma,except for one SNP shared with hay fever.
First Author:
V. Ullemar
Correspondence:
Vilhelmina Ullemar, Department of Medical Epidemiology and Biostatistics
All Authors:
V. Ullemar, P. K. E. Magnusson, C. Lundholm, A. Zettergren, E. Melen , P. Lichtenstein&C. Almqvist
——来自浙大迪迅
① 哮喘的遗传学已经广泛地使用定量和分子遗传学分析方法进行研究，但是两种方法都缺乏针对儿童表型和其他过敏性疾病特异性的研究；② 纳入25306对9岁或12岁的瑞典双胞胎；③ 对10075对双胞胎的子集进行16个单核苷酸多态性（SNP）的基因分型，这些单核苷酸多态性选自先前的GWAS；④ 儿童哮喘的遗传力为0.82；⑤ IL1RL1中只有rs3771180与其他过敏性疾病相关（对于花粉热）。
延伸阅读
Allergy
[IF:6.048]
Heritability and confirmation of genetic association studies for childhood asthma in twinsDOI: 10.1111/all.12783
Abstract:
Background: Although the genetics of asthma has been extensively studied using both quantitative and molecular genetic analysis methods, both approaches lack studies specific to the childhood phenotype and including other allergic diseases.This study aimed to give specific estimates for the heritability of childhood asthma and other allergic diseases, to attempt to replicate findings from genomewide association studies (GWAS) for childhood asthma and to test the same variants against other allergic diseases.
Methods: In a cohort of 25 306 Swedish twins aged 9 or 12 years, data on asthma were available from parental interviews and population-based registers. The interviews also inquired about wheeze, hay fever, eczema, and food allergy. Through structural equation modeling, the heritability of all phenotypes was calculated. A subset of 10 075 twins was genotyped for 16 single nucleotide polymorphisms (SNPs) selected from previous GWAS; these were first tested for association with asthma and significant findings also against the other allergic diseases.
Results: The heritability of any childhood asthma was 0.82 (95% CI 0.79–0.85).For the other allergic diseases, the range was approximately 0.60–0.80. Associations for six SNPs with asthma were replicated, including rs2305480 in the GSDMB gene (OR 0.80, 95% CI 0.74–0.86, P = 1.5*108; other significant associations all below P = 3.5*10^4). Of these, only rs3771180 in IL1RL1 was associated with any other allergic disease (for hay fever, OR 0.64, 95% CI 0.53–0.77, P = 2.5*10^6).
Conclusions: Asthma and allergic diseases of childhood are highly heritable, and these high-risk genetic variants associated specifically with childhood asthma,except for one SNP shared with hay fever.
First Author:
V. Ullemar
Correspondence:
Vilhelmina Ullemar, Department of Medical Epidemiology and Biostatistics
All Authors:
V. Ullemar, P. K. E. Magnusson, C. Lundholm, A. Zettergren, E. Melen , P. Lichtenstein&C. Almqvist
2018-11-18 Article
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
