杭州浙大迪迅生物基因工程有限公司JACI：大豆过敏的组份研究
发布日期：2018-12-18
原标题：大豆过敏的分子组份检测分析
④分子组份过敏检测在评估大豆过敏风险和建立适当的医疗应答方面迈出了重要的一步。在识别系统反应和局部/非特异性反应上，它们的标记物之间存在显着特异性，表明该信息对患者及其家属有重要意义。
延伸阅读
JACI:
DOI: https://doi.org/10.1016/j.jaci.2017.12.843 Abstract:
Background
Rationale
Soy allergy is one of the most common food allergies. The presence of IgE specific to soy component storage proteins Gly m4, m5, and m6 has been indicated as a means to improve the specific identification of systemic and local soy allergic reactions.
Methods
A retrospective review of national laboratory data was performed over samples testing for IgE to Gly m4, 5, and 6 (Phadia ImmunoCAP). Data from de-identified patient samples were compiled into risk groups based on current research utilizing the international standard cutoff of 0.35kU/L as a positive test for IgE.
Results
Of the sample set, 46% of patients were responsive to at least one soy component. Of these, 39% of patients display response to only Gly m5 and 6, the components most indicative of a severe and systemic response to soy. Patients responsive to Gly m4 only represented 37%, and 15% were responsive to all components. Few patients were responsive to Gly m5 or 6 separately or associated with Gly m4. Nearly 60% of positive pediatric (<10Y) patients were responsive to both Gly m5 and 6 and only 14% to Gly m4 alone. Patients older than 10 years predominantly respond to Gly m4 alone over m5 and m6 only (54% to 24%).
Conclusions
Molecular component allergy testing represents a major step forward in assessing risk of soy allergies and constructing an appropriate medical response. A significant rate of specificity between the identification of markers for systemic and local/non-specific reactions indicates the importance of this information for patients and their families.
All Author:
Dallas C. Jones, Amanda L. Hays Michelle L. Altrich PhD
——来自浙大迪迅
①大豆过敏是最常见的食物过敏之一。大豆组分贮藏蛋白Gly m4、m5、m6特异性IgE检测，被认为是提高大豆过敏反应（系统性和局部）特异性鉴定能力的一种方法②本研究回顾性分析了国家实验室对样本进行Gly m4、5、6特异性 IgE (Phadia ImmunoCAP)检测的结果。根据目前的研究，利用国际标准0.35kU/L作为IgE检测阳性的临界值，将未鉴定的患者样本的数据编入危险组。③在样本组中，46%的患者对至少一种大豆组份有反应。在这些患者中，39%的患者仅对Gly m5和Gly 6有反应，这两种成分最能说明大豆对患者有严重的全身反应。对Gly m4有反应的患者仅占37%，对所有成分均有反应的患者占15%。少数患者单独对Gly m5或6有反应或与Gly m4相关。近60% (<10岁)阳性患儿对Gly m5和6均有应答，仅14%对Gly m4有应答。大于10岁的患者对Gly m4的反应明显高于m5和m6(54% - 24%)。④分子组份过敏检测在评估大豆过敏风险和建立适当的医疗应答方面迈出了重要的一步。在识别系统反应和局部/非特异性反应上，它们的标记物之间存在显着特异性，表明该信息对患者及其家属有重要意义。
延伸阅读
JACI:
[IF:13.1]
Analysis of Soy Allergy Using Molecular Component TestingDOI: https://doi.org/10.1016/j.jaci.2017.12.843 Abstract:
Background
Rationale
Soy allergy is one of the most common food allergies. The presence of IgE specific to soy component storage proteins Gly m4, m5, and m6 has been indicated as a means to improve the specific identification of systemic and local soy allergic reactions.
Methods
A retrospective review of national laboratory data was performed over samples testing for IgE to Gly m4, 5, and 6 (Phadia ImmunoCAP). Data from de-identified patient samples were compiled into risk groups based on current research utilizing the international standard cutoff of 0.35kU/L as a positive test for IgE.
Results
Of the sample set, 46% of patients were responsive to at least one soy component. Of these, 39% of patients display response to only Gly m5 and 6, the components most indicative of a severe and systemic response to soy. Patients responsive to Gly m4 only represented 37%, and 15% were responsive to all components. Few patients were responsive to Gly m5 or 6 separately or associated with Gly m4. Nearly 60% of positive pediatric (<10Y) patients were responsive to both Gly m5 and 6 and only 14% to Gly m4 alone. Patients older than 10 years predominantly respond to Gly m4 alone over m5 and m6 only (54% to 24%).
Conclusions
Molecular component allergy testing represents a major step forward in assessing risk of soy allergies and constructing an appropriate medical response. A significant rate of specificity between the identification of markers for systemic and local/non-specific reactions indicates the importance of this information for patients and their families.
All Author:
Dallas C. Jones, Amanda L. Hays Michelle L. Altrich PhD
2018-12-12 Article
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
